Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes

Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes

Abstract Background The CD4-induced (CD4i) epitopes in gp120 includes the co-receptor binding site, which are formed and exposed after interaction with CD4. Monoclonal antibodies (mAbs) to the CD4i epitopes exhibit limited neutralizing activity because of restricted access to their epitopes. However...

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Bibliographic Details
Main Authors: Kazuki Tanaka, Takeo Kuwata, Muntasir Alam, Gilad Kaplan, Shokichi Takahama, Kristel Paola Ramirez Valdez, Anna Roitburd-Berman, Jonathan M. Gershoni, Shuzo Matsushita
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Retrovirology
Subjects:
HIV-1 neutralizing antibody
scFv
CD4i epitopes
Bridging sheet
Online Access:http://link.springer.com/article/10.1186/s12977-017-0369-y

Internet

http://link.springer.com/article/10.1186/s12977-017-0369-y

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