TET family regulates the embryonic pluripotency of porcine preimplantation embryos by maintaining the DNA methylation level of NANOG

TET family regulates the embryonic pluripotency of porcine preimplantation embryos by maintaining the DNA methylation level of NANOG

The ten-eleven translocation (TET) family (TET1/2/3) initiates conversion of 5-methylcytosine to 5-hydroxymethylcytosine, thereby orchestrating the DNA demethylation process and changes in epigenetic marks during early embryogenesis. In this study, CRISPR/Cas9 technology and a TET-specific inhibitor...

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Bibliographic Details
Main Authors: Kyungjun Uh, Junghyun Ryu, Kayla Farrell, Noah Wax, Kiho Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2020-11-01
Series:Epigenetics
Subjects:
tet
methylcytosine dioxygenase
dna methylation
pluripotency
embryo
porcine
Online Access:http://dx.doi.org/10.1080/15592294.2020.1762392

Internet

http://dx.doi.org/10.1080/15592294.2020.1762392

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