Accelerated Generation of Extra-Islet Insulin-Producing Cells in Diabetic Rats, Treated with Sodium Phthalhydrazide

Accelerated Generation of Extra-Islet Insulin-Producing Cells in Diabetic Rats, Treated with Sodium Phthalhydrazide

β-cells dysfunction plays an important role in the pathogenesis of type 2 diabetes (T2D), partially may be compensated by the generation of extra-islet insulin-producing cells (IPCs) in pancreatic acini and ducts. Pdx1 expression and inflammatory level are suggested to be involved in the generation...

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Bibliographic Details
Main Authors: Musa T. Abidov, Ksenia V. Sokolova, Irina F. Gette, Irina G. Danilova
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
extra-islet insulin-producing cell
macrophage
macrophage plasticity
immunomodulators
sodium aminophthalhydrazide
streptozotocin-nicotinamide-induced diabetes
Online Access:https://www.mdpi.com/1422-0067/23/8/4286

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https://www.mdpi.com/1422-0067/23/8/4286

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