Codonopsis pilosula polysaccharide alleviates rotenone-induced murine brain organoids death through downregulation of gene body DNA methylation modification in the ZIC4/PGM5/CAMTA1 axis

Codonopsis pilosula polysaccharide alleviates rotenone-induced murine brain organoids death through downregulation of gene body DNA methylation modification in the ZIC4/PGM5/CAMTA1 axis

Here, the protective mechanism of Codonopsis pilosula polysaccharide (CpP) against mouse brain organoids (mBO) damage was analyzed, and the rotenone affected the genomic epigenetic modifications and physiological activity of mouse brain organoids was examined. Pathological experiments have shown tha...

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Bibliographic Details
Main Authors: Haiyang Chen, Yichao Wen, Zhihua Yu, Xiling Du, Weidong Pan, Te Liu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Rotenone
Brain organoid
Codonopsis pilosula polysaccharide
DNA methylation
ZIC4/PGM5/CAMTA1 axis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580823001747

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http://www.sciencedirect.com/science/article/pii/S2405580823001747

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