Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5/KLF4 signaling pathway

Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5/KLF4 signaling pathway

Abstract Low fluid shear stress (FSS, ≤ 2 dyn/cm2) has been shown to exert protective effects on chondrocytes, but the underlying molecular mechanisms remain unclear. This study aimed to elucidate the mechanisms by which FSS promotes chondrocyte proliferation and extracellular matrix (ECM) stability...

Full description

Bibliographic Details
Main Authors: Jun Zhao, Yayi Xia, Jinwen He
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Fluid shear stress
MiR-143-3p
Extracellular signal-regulated kinase 5
Chondrocyte
Proliferation
Online Access:https://doi.org/10.1038/s41598-024-78676-w

Internet

https://doi.org/10.1038/s41598-024-78676-w

Similar Items