Copper deposition in Wilson’s disease causes male fertility decline by impairing reproductive hormone release through inducing apoptosis and inhibiting ERK signal in hypothalamic-pituitary of mice

Copper deposition in Wilson’s disease causes male fertility decline by impairing reproductive hormone release through inducing apoptosis and inhibiting ERK signal in hypothalamic-pituitary of mice

Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism characterized by liver and central nervous system dysfunction. Considerable evidence suggests that infertility is also very common in male patients with WD, but the exact molecular mechanisms involved remain unknown. In or...

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Bibliographic Details
Main Authors: Tingting Wang, Limin Wu, Qiuying Chen, Kuiyu Chen, Fang Tan, Jiabo Liu, Xiang Liu, Hui Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Endocrinology
Subjects:
Wilson’s disease
reproductive neuroendocrine
infertility
hypothalamic–pituitary–testicular axis
apoptosis
extracellular regulatory protein kinase1/2 (ERK1/2)
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.961748/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.961748/full

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