Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice

Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice

The low density lipoprotein receptor (LDLR) plays a major role in regulation of plasma cholesterol levels as a ligand for apolipoprotein B-100 and apolipoprotein E (apoE). Consequently, LDLR-deficient mice fed a Western-type diet develop significant hypercholesterolemia and atherosclerosis. ApoE not...

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Bibliographic Details
Main Authors: Masa-aki Kawashiri, Yuzhen Zhang, David Usher, Muredach Reilly, Ellen Puré, Daniel J. Rader
Format: Article
Language:English
Published: Elsevier 2001-06-01
Series:Journal of Lipid Research
Subjects:
low density lipoprotein receptor
lipoprotein metabolism
gene transfer
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520316187

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http://www.sciencedirect.com/science/article/pii/S0022227520316187

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