Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice
The low density lipoprotein receptor (LDLR) plays a major role in regulation of plasma cholesterol levels as a ligand for apolipoprotein B-100 and apolipoprotein E (apoE). Consequently, LDLR-deficient mice fed a Western-type diet develop significant hypercholesterolemia and atherosclerosis. ApoE not...
Main Authors: | Masa-aki Kawashiri, Yuzhen Zhang, David Usher, Muredach Reilly, Ellen Puré, Daniel J. Rader |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2001-06-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520316187 |
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