Genetic alterations and molecular mechanisms underlying hereditary intrahepatic cholestasis

Genetic alterations and molecular mechanisms underlying hereditary intrahepatic cholestasis

Hereditary cholestatic liver disease caused by a class of autosomal gene mutations results in jaundice, which involves the abnormality of the synthesis, secretion, and other disorders of bile acids metabolism. Due to the existence of a variety of gene mutations, the clinical manifestations of childr...

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Bibliographic Details
Main Authors: Shuying Xie, Shizhang Wei, Xiao Ma, Ruilin Wang, Tingting He, Zhao Zhang, Ju Yang, Jiawei Wang, Lei Chang, Manyi Jing, Haotian Li, Xuelin Zhou, Yanling Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
heredity
intrahepatic cholestasis
genetic mutation
molecular function
therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1173542/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1173542/full

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