Tumor Necrosis Factor and Interleukin-1β Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation

Tumor Necrosis Factor and Interleukin-1β Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), utilizes the host receptor angiotensin-converting enzyme 2 (ACE2) and the auxiliary receptor Neuropilin-1 (NRP1) to enter host cells. NRP1 has another isoform, NRP2, whose function in COVI...

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Bibliographic Details
Main Authors: Michinori Ishitoku, Sho Mokuda, Kei Araki, Hirofumi Watanabe, Hiroki Kohno, Tomohiro Sugimoto, Yusuke Yoshida, Takemasa Sakaguchi, Junya Masumoto, Shintaro Hirata, Eiji Sugiyama
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Viruses
Subjects:
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
coronavirus disease 2019 (COVID-19)
Neuropilin-1 (NRP1)
Neuropilin-2 (NRP2)
tumor necrosis factor alpha (TNFα)
Online Access:https://www.mdpi.com/1999-4915/15/7/1498

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https://www.mdpi.com/1999-4915/15/7/1498

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