Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant

Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant

Abstract Background Phlebotomus papatasi vectors zoonotic cutaneous leishmaniasis. Previous expression of recombinant P. papatasi acetylcholinesterase (PpAChE1) revealed 85% amino acid sequence identity to mosquito AChE and identified synthetic carbamates that effectively inhibited PpAChE1 with impr...

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Bibliographic Details
Main Authors: Kevin B Temeyer, Fan Tong, Maxim M Totrov, Alexander P Tuckow, Qiao-hong Chen, Paul R Carlier, Adalberto A Pérez de León, Jeffrey R Bloomquist
Format: Article
Language:English
Published: BMC 2014-12-01
Series:Parasites & Vectors
Subjects:
Sand fly
Acetylcholinesterase inhibition
P. papatasi
cDNA
AChE
Online Access:https://doi.org/10.1186/s13071-014-0577-4

Internet

https://doi.org/10.1186/s13071-014-0577-4

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