Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions.

Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions.

Expression of Heat Shock Protein-27 (HSP27) is reduced in human coronary atherosclerosis. Over-expression of HSP27 is protective against the early formation of lesions in atherosclerosis-prone apoE(-/-) mice (apoE(-/-)HSP27(o/e)) - however, only in females. We now seek to determine if chronic HSP27...

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Bibliographic Details
Main Authors: Charles M Cuerrier, Yong-Xiang Chen, Dominique Tremblay, Katey Rayner, Melissa McNulty, XiaoLing Zhao, Christopher R J Kennedy, Jacqueline de BelleRoche, Andrew E Pelling, Edward R O'Brien
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3567023?pdf=render

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http://europepmc.org/articles/PMC3567023?pdf=render

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