A Novel Approach for the Simultaneous Analysis of Common and Rare Variants in Complex Traits

Genome-wide association studies (GWAS) have been successful in detecting common genetic variants underlying common traits and diseases. Despite the GWAS success stories, the percent trait variance explained by GWAS signals, the so called “missing heritability” has been, at best, modest. Also, the pr...

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Bibliographic Details
Main Authors: Ao Yuan, Guanjie Chen, Yanxun Zhou, Amy Bentley, Charles Rotimi
Format: Article
Language:English
Published: SAGE Publishing 2012-01-01
Series:Bioinformatics and Biology Insights
Online Access:https://doi.org/10.4137/BBI.S8852