Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction

Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction

Drug repositioning continues to be the most effective, practicable possibility to treat COVID-19 patients. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus enters target cells by binding to the ACE2 receptor via its spike (S) glycoprotein. We used molecular docking-based virtua...

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Bibliographic Details
Main Authors: Shahzaib Ahamad, Hashim Ali, Ilaria Secco, Mauro Giacca, Dinesh Gupta
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Genetics
Subjects:
SARS-CoV-2
COVID-19
ACE2
virtual screening
MD simulations
syncytia
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.866474/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.866474/full

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