Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation

Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation

Recent advances in DNA sequencing technologies are revealing a large individual variability of the human genome. Our capacity to establish genotype-phenotype correlations in such large-scale is, however, limited. This task is particularly challenging due to the multifunctional nature of many protein...

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Bibliographic Details
Main Authors: Juan Luis Pacheco-Garcia, Matteo Cagiada, Kelly Tienne-Matos, Eduardo Salido, Kresten Lindorff-Larsen, Angel L. Pey
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
protein function
protein stability
genotype-phenotype correlations
computational prediction
sequence conservation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1063620/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1063620/full

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