Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells

Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells

CDK2 can drive the proliferation of cancer cells. Here, the authors screened for a non-ATP competitive inhibitor of the CDK2/cylinA complex and find that Homoharringtonine can disrupt the complex and promote the degradation of CDK2.

Bibliographic Details
Main Authors: Jiawei Zhang, Yichao Gan, Hongzhi Li, Jie Yin, Xin He, Liming Lin, Senlin Xu, Zhipeng Fang, Byung-wook Kim, Lina Gao, Lili Ding, Eryun Zhang, Xiaoxiao Ma, Junfeng Li, Ling Li, Yang Xu, David Horne, Rongzhen Xu, Hua Yu, Ying Gu, Wendong Huang
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30264-0

Internet

https://doi.org/10.1038/s41467-022-30264-0

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