Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells
CDK2 can drive the proliferation of cancer cells. Here, the authors screened for a non-ATP competitive inhibitor of the CDK2/cylinA complex and find that Homoharringtonine can disrupt the complex and promote the degradation of CDK2.
Bibliographic Details
| Main Authors: |
Jiawei Zhang,
Yichao Gan,
Hongzhi Li,
Jie Yin,
Xin He,
Liming Lin,
Senlin Xu,
Zhipeng Fang,
Byung-wook Kim,
Lina Gao,
Lili Ding,
Eryun Zhang,
Xiaoxiao Ma,
Junfeng Li,
Ling Li,
Yang Xu,
David Horne,
Rongzhen Xu,
Hua Yu,
Ying Gu,
Wendong Huang |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2022-05-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-022-30264-0
|
|---|