EGFR-mediated activation of adipose tissue macrophages promotes obesity and insulin resistance

EGFR-mediated activation of adipose tissue macrophages promotes obesity and insulin resistance

In obesity, adipose tissue is chronically inflamed, leading to insulin resistance, and adipose tissue macrophages (ATMs) are a major source of cytokines that aggravate adipocyte dysfunction. Here, the authors show that selective deletion of the epidermal growth factor receptor in ATMs decreased obes...

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Bibliographic Details
Main Authors: Shirong Cao, Yu Pan, Jiaqi Tang, Andrew S. Terker, Juan Pablo Arroyo Ornelas, Guan-nan Jin, Yinqiu Wang, Aolei Niu, Xiaofeng Fan, Suwan Wang, Raymond C. Harris, Ming-Zhi Zhang
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32348-3

Internet

https://doi.org/10.1038/s41467-022-32348-3

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