EGFR-mediated activation of adipose tissue macrophages promotes obesity and insulin resistance
In obesity, adipose tissue is chronically inflamed, leading to insulin resistance, and adipose tissue macrophages (ATMs) are a major source of cytokines that aggravate adipocyte dysfunction. Here, the authors show that selective deletion of the epidermal growth factor receptor in ATMs decreased obes...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32348-3 |
| _version_ | 1828749527127949312 |
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| author | Shirong Cao Yu Pan Jiaqi Tang Andrew S. Terker Juan Pablo Arroyo Ornelas Guan-nan Jin Yinqiu Wang Aolei Niu Xiaofeng Fan Suwan Wang Raymond C. Harris Ming-Zhi Zhang |
| author_facet | Shirong Cao Yu Pan Jiaqi Tang Andrew S. Terker Juan Pablo Arroyo Ornelas Guan-nan Jin Yinqiu Wang Aolei Niu Xiaofeng Fan Suwan Wang Raymond C. Harris Ming-Zhi Zhang |
| author_sort | Shirong Cao |
| collection | DOAJ |
| description | In obesity, adipose tissue is chronically inflamed, leading to insulin resistance, and adipose tissue macrophages (ATMs) are a major source of cytokines that aggravate adipocyte dysfunction. Here, the authors show that selective deletion of the epidermal growth factor receptor in ATMs decreased obesity and development of insulin resistance. |
| first_indexed | 2024-12-10T20:24:06Z |
| format | Article |
| id | doaj.art-ac85aa9123a84c29b4a497e827a2724b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T20:24:06Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ac85aa9123a84c29b4a497e827a2724b2022-12-22T01:34:56ZengNature PortfolioNature Communications2041-17232022-08-0113111610.1038/s41467-022-32348-3EGFR-mediated activation of adipose tissue macrophages promotes obesity and insulin resistanceShirong Cao0Yu Pan1Jiaqi Tang2Andrew S. Terker3Juan Pablo Arroyo Ornelas4Guan-nan Jin5Yinqiu Wang6Aolei Niu7Xiaofeng Fan8Suwan Wang9Raymond C. Harris10Ming-Zhi Zhang11Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical CenterDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical CenterDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical CenterDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical CenterDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical CenterDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical CenterDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical CenterDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical CenterDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical CenterDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical CenterDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical CenterDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical CenterIn obesity, adipose tissue is chronically inflamed, leading to insulin resistance, and adipose tissue macrophages (ATMs) are a major source of cytokines that aggravate adipocyte dysfunction. Here, the authors show that selective deletion of the epidermal growth factor receptor in ATMs decreased obesity and development of insulin resistance.https://doi.org/10.1038/s41467-022-32348-3 |
| spellingShingle | Shirong Cao Yu Pan Jiaqi Tang Andrew S. Terker Juan Pablo Arroyo Ornelas Guan-nan Jin Yinqiu Wang Aolei Niu Xiaofeng Fan Suwan Wang Raymond C. Harris Ming-Zhi Zhang EGFR-mediated activation of adipose tissue macrophages promotes obesity and insulin resistance Nature Communications |
| title | EGFR-mediated activation of adipose tissue macrophages promotes obesity and insulin resistance |
| title_full | EGFR-mediated activation of adipose tissue macrophages promotes obesity and insulin resistance |
| title_fullStr | EGFR-mediated activation of adipose tissue macrophages promotes obesity and insulin resistance |
| title_full_unstemmed | EGFR-mediated activation of adipose tissue macrophages promotes obesity and insulin resistance |
| title_short | EGFR-mediated activation of adipose tissue macrophages promotes obesity and insulin resistance |
| title_sort | egfr mediated activation of adipose tissue macrophages promotes obesity and insulin resistance |
| url | https://doi.org/10.1038/s41467-022-32348-3 |
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