The evolved divergence of γ-secretase-susceptibility of homologous proteins Ngfrb and Nradd in zebrafish

Abstract Objective NGFR/p75NTR and NRADD/NRH proteins are closely related structurally and are encoded by genes that arose from a duplication event early in vertebrate evolution. The transmembrane domain (TMD) of NGFR is cleaved by γ-secretase but there is conflicting data around the susceptibility...

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Bibliographic Details
Main Authors: Tanya Jayne, Morgan Newman, Lachlan Baer, Michael Lardelli
Format: Article
Language:English
Published: BMC 2021-12-01
Series:BMC Research Notes
Subjects:
Online Access:https://doi.org/10.1186/s13104-021-05876-2