Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation

Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation

Ceramide is an important constituent of stratum corneum lipids, which act as both physical barriers and signal modulators. We synthesized several ceramide derivatives and investigated their effects on keratinocyte differentiation. RT-PCR and Western blotting showed that the novel synthetic ceramide...

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Bibliographic Details
Main Authors: Yoo Bin Kwon, Chang Deok Kim, Jong-Kyung Youm, Hyung Sub Gwak, Byeong Deog Park, Seung Hun Lee, Saewha Jeon, Bo Joong Kim, Young-Joon Seo, Jang-Kyu Park, Jeung-Hoon Lee
Format: Article
Language:English
Published: Elsevier 2007-09-01
Series:Journal of Lipid Research
Subjects:
K6PC-4
K6PC-5
K6PC-9
intracellular calcium level
mitogen-activated protein kinase
keratin 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520424812

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http://www.sciencedirect.com/science/article/pii/S0022227520424812

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