Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency

Human cytomegalovirus (HCMV) infection is shaped by a tightly regulated interplay between viral and cellular proteins. Distinct kinase activities, such as the viral cyclin-dependent kinase ortholog (vCDK) pUL97 and cellular CDK7 are both crucial for efficient viral replication. Previously, we report...

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Bibliographic Details
Main Authors: Martin Schütz, Christina Wangen, Mona Sommerer, Melanie Kögler, Jan Eickhoff, Carsten Degenhart, Bert Klebl, Zin Naing, Ece Egilmezer, Stuart T. Hamilton, William D. Rawlinson, Heinrich Sticht, Manfred Marschall
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Virus Research
Subjects:
Human cytomegalovirus
Viral cyclin-dependent kinase (CDK) ortholog
vCDK/pUL97–cyclin binding
Functional importance of cyclin H
Modulation of vCDK/pUL97 activity in vitro
Cyclin H knock-down
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170223001624

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http://www.sciencedirect.com/science/article/pii/S0168170223001624

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