Diversity of Structural, Dynamic, and Environmental Effects Explain a Distinctive Functional Role of Transmembrane Domains in the Insulin Receptor Subfamily

Diversity of Structural, Dynamic, and Environmental Effects Explain a Distinctive Functional Role of Transmembrane Domains in the Insulin Receptor Subfamily

Human InsR, IGF1R, and IRR receptor tyrosine kinases (RTK) of the insulin receptor subfamily play an important role in signaling pathways for a wide range of physiological processes and are directly associated with many pathologies, including neurodegenerative diseases. The disulfide-linked dimeric...

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Bibliographic Details
Main Authors: Yaroslav V. Bershatsky, Andrey S. Kuznetsov, Aisha R. Idiatullina, Olga V. Bocharova, Sofya M. Dolotova, Alina A. Gavrilenkova, Oxana V. Serova, Igor E. Deyev, Tatiana V. Rakitina, Olga T. Zangieva, Konstantin V. Pavlov, Oleg V. Batishchev, Vladimir V. Britikov, Sergey A. Usanov, Alexander S. Arseniev, Roman G. Efremov, Eduard V. Bocharov
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
receptor tyrosine kinases
insulin receptor subfamily
transmembrane domain
structural-dynamical properties
protein-lipid interactions
NMR
Online Access:https://www.mdpi.com/1422-0067/24/4/3906

Internet

https://www.mdpi.com/1422-0067/24/4/3906

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