Icariside II, a Phosphodiesterase-5 Inhibitor, Attenuates Beta-Amyloid-Induced Cognitive Deficits via BDNF/TrkB/CREB Signaling

Icariside II, a Phosphodiesterase-5 Inhibitor, Attenuates Beta-Amyloid-Induced Cognitive Deficits via BDNF/TrkB/CREB Signaling

Background/Aims: Icariside II (ICS II) is an active component from Epimedium brevicornum, a Chinese medicine extensively used in China. Our previous study has proved that ICS II protects against learning and memory impairments and neuronal apoptosis in the hippocampus induced by beta-amyloid25-35 (A...

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Bibliographic Details
Main Authors: Shuang Liu, Xiaohui Li, Jianmei Gao, Yuangui Liu, Jingshan Shi, Qihai Gong
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Icariside II
Alzheimer’s disease
Brain-derived neurotrophic factortyrosine receptor kinase
Tyrosine receptor kinase B
cAMP response element binding
Online Access:https://www.karger.com/Article/FullText/493232

Internet

https://www.karger.com/Article/FullText/493232

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