Altered Fhod3 expression involved in progressive high-frequency hearing loss via dysregulation of actin polymerization stoichiometry in the cuticular plate.

Altered Fhod3 expression involved in progressive high-frequency hearing loss via dysregulation of actin polymerization stoichiometry in the cuticular plate.

Age-related hearing loss (ARHL) is a common sensory impairment with complex underlying mechanisms. In our previous study, we performed a meta-analysis of genome-wide association studies (GWAS) in mice and identified a novel locus on chromosome 18 associated with ARHL specifically linked to a 32 kHz...

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Bibliographic Details
Main Authors: Ely Cheikh Boussaty, Yuzuru Ninoyu, Leonardo R Andrade, Qingzhong Li, Ryu Takeya, Hideki Sumimoto, Takahiro Ohyama, Karl J Wahlin, Uri Manor, Rick A Friedman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-03-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011211

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https://doi.org/10.1371/journal.pgen.1011211

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