Inhibition of SARS-CoV-2 replication by a ssDNA aptamer targeting the nucleocapsid protein

Inhibition of SARS-CoV-2 replication by a ssDNA aptamer targeting the nucleocapsid protein

ABSTRACTThe nucleocapsid protein of SARS-CoV-2 plays significant roles in viral assembly, immune evasion, and viral stability. Due to its immunogenicity, high expression levels during COVID-19, and conservation across viral strains, it represents an attractive target for antiviral treatment. In this...

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Bibliographic Details
Main Authors: Yanping Huang, Congcong Huang, Junkai Chen, Siwei Chen, Bei Li, Jian Li, Zhixiong Jin, Qiwei Zhang, Pan Pan, Weixing Du, Long Liu, Zhixin Liu
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
nucleocapsid protein
aptamer
antiviral therapy
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03410-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.03410-23

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