Inhibition of Erythrocyte Cell Membrane Scrambling by ASP3026

Inhibition of Erythrocyte Cell Membrane Scrambling by ASP3026

Background/Aims: The anaplastic lymphoma kinase (ALK) inhibitor ASP3026 is in clinical development for the treatment of ALK expressing non-small cell lung carcinoma (NSCLC). ASP3026 is in part effective by inducing apoptosis of tumor cells. Erythrocytes lack mitochondria and nuclei, key organelles i...

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Bibliographic Details
Main Authors: Abdulla Al Mamun Bhuyan, Rosi Bissinger, Hang Cao, Florian Lang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Phosphatidylserine
Eryptosis
Energy depletion
Oxidative stress
Ionomycin
Calcium
Online Access:http://www.karger.com/Article/FullText/480477

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http://www.karger.com/Article/FullText/480477

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