Autotaxin inhibition attenuates the aortic valve calcification by suppressing inflammation-driven fibro-calcific remodeling of valvular interstitial cells

Autotaxin inhibition attenuates the aortic valve calcification by suppressing inflammation-driven fibro-calcific remodeling of valvular interstitial cells

Abstract Background Patients with fibro-calcific aortic valve disease (FCAVD) have lipid depositions in their aortic valve that engender a proinflammatory impetus toward fibrosis and calcification and ultimately valve leaflet stenosis. Although the lipoprotein(a)-autotaxin (ATX)-lysophosphatidic aci...

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Bibliographic Details
Main Authors: Dohee Yoon, Bongkun Choi, Ji-Eun Kim, Eun-Young Kim, Soo-Hyun Chung, Hyo-Jin Min, Yoolim Sung, Eun-Ju Chang, Jae-Kwan Song
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Medicine
Subjects:
Fibro-calcific aortic valve disease
Autotaxin
Aortic valve
Fibrosis
Calcification
Online Access:https://doi.org/10.1186/s12916-024-03342-x

Internet

https://doi.org/10.1186/s12916-024-03342-x

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