LncRNA KCNQ1OT1 sponges miR-15a to promote immune evasion and malignant progression of prostate cancer via up-regulating PD-L1

LncRNA KCNQ1OT1 sponges miR-15a to promote immune evasion and malignant progression of prostate cancer via up-regulating PD-L1

Abstract Background We focused on the KCNQ1OT1/miR-15a/PD-L1 axis and explored its significance in regulating immune evasion and malignant behaviors of prostate cancer (PC) cells. Methods The expression levels of KCNQ1OT1, miR-15a, PD-L1, and CD8 in cells or tissues were examined by RT-qPCR, western...

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Bibliographic Details
Main Authors: Qi-Hua Chen, Bo Li, De-Guo Liu, Biao Zhang, Xian Yang, Ya-Ling Tu
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Cancer Cell International
Subjects:
Prostate cancer
KCNQ1OT1
MiR-15a
PD-L1
Immune evasion
Online Access:http://link.springer.com/article/10.1186/s12935-020-01481-8

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http://link.springer.com/article/10.1186/s12935-020-01481-8

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