Rosiglitazone Promotes AQP2 Plasma Membrane Expression In Renal Cells Via a Ca2+-Dependent/cAMP-Independent Mechanism

Rosiglitazone Promotes AQP2 Plasma Membrane Expression In Renal Cells Via a Ca2+-Dependent/cAMP-Independent Mechanism

Background/Aims: Thiazolidinediones are highly beneficial in the treatment of type II diabetes. However, they are also associated with edema and increased risk of congestive heart failure. Several studies demonstrated that rosiglitazone (RGZ) increases the abundance of aquaporin-2 (AQP2) at the plas...

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Bibliographic Details
Main Authors: Giuseppe Procino, Andrea Gerbino, Serena Milano, Maria Celeste Nicoletti, Lisa Mastrofrancesco, Monica Carmosino, Maria Svelto
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Edema
Aquaporin 2
Vasopressin
Thiazolidinediones
Rosiglitazone
Calcium signaling
Transient receptor potential
Online Access:http://www.karger.com/Article/FullText/373933

Internet

http://www.karger.com/Article/FullText/373933

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