Decoy oligonucleotide rescues IGF1R expression from MicroRNA-223 suppression.

Decoy oligonucleotide rescues IGF1R expression from MicroRNA-223 suppression.

A mature miRNA generally suppresses hundreds of mRNA targets. To evaluate the selective effect of synthetic oligonucleotide decoys on hsa-miR-223 activity, reporters containing 3' untranslated regions (UTR) of IGF1R, FOXO1, POLR3G, FOXO3, CDC27, FBXW7 and PAXIP1 mRNAs were constructed for the l...

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Bibliographic Details
Main Authors: Li Hui Wu, Qian Qian Cai, Yi Wei Dong, Rong Wang, Bao Mei He, Bing Qi, Chang Jun Xu, Xing Zhong Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3852755?pdf=render

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http://europepmc.org/articles/PMC3852755?pdf=render

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