Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice

Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice

Background Ischemia/reperfusion injury impairs proteostasis, and triggers adaptive cellular responses, such as the unfolded protein response (UPR), which functions to restore endoplasmic reticulum homeostasis. After cardiac arrest (CA) and resuscitation, the UPR is activated in various organs includ...

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Bibliographic Details
Main Authors: Yuntian Shen, Ran Li, Shu Yu, Qiang Zhao, Zhuoran Wang, Huaxin Sheng, Wei Yang
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
brain ischemia
ER stress
ER‐associated degradation
neuroprotection
RNA‐Seq
transgenic mice
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.020216

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.020216

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