Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment

Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment

Abstract Intermittent injections of parathyroid hormone (iPTH) are applied clinically to stimulate bone formation by osteoblasts, although continuous elevation of parathyroid hormone (PTH) primarily results in increased bone resorption. Here, we identified Calca, encoding the sepsis biomarker procal...

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Bibliographic Details
Main Authors: Anke Baranowsky, Denise Jahn, Shan Jiang, Timur Yorgan, Peter Ludewig, Jessika Appelt, Kai K. Albrecht, Ellen Otto, Paul Knapstein, Antonia Donat, Jack Winneberger, Lana Rosenthal, Paul Köhli, Cordula Erdmann, Melanie Fuchs, Karl-Heinz Frosch, Serafeim Tsitsilonis, Michael Amling, Thorsten Schinke, Johannes Keller
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-021-00172-y

Internet

https://doi.org/10.1038/s41413-021-00172-y

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