Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation

Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation

Targeting oxidative phosphorylation (OXPHOS) is a promising strategy to improve treatment outcomes of acute myeloid leukemia (AML) patients. IACS-010759 is a mitochondrial complex I inhibitor that has demonstrated preclinical antileukemic activity and is being tested in Phase I clinical trials. Howe...

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Bibliographic Details
Main Authors: Fangbing Liu, Hasini A. Kalpage, Deying Wang, Holly Edwards, Maik Hüttemann, Jun Ma, Yongwei Su, Jenna Carter, Xinyu Li, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Guan Wang, Jeffrey W. Taub, Yubin Ge
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
acute myeloid leukemia
Bcl-2
venetoclax
IACS-010759
oxidative phosphorylation
Online Access:https://www.mdpi.com/2072-6694/12/9/2400

Internet

https://www.mdpi.com/2072-6694/12/9/2400

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