Interleukin 37 Suppresses M1 Macrophage Polarization Through Inhibition of the Notch1 and Nuclear Factor Kappa B Pathways

Interleukin 37 Suppresses M1 Macrophage Polarization Through Inhibition of the Notch1 and Nuclear Factor Kappa B Pathways

Macrophage-orchestrated chronic inflammation plays an important role in cardiovascular disease, including accelerating the development of calcific aortic valve disease (CAVD). M1 and M2 macrophage polarization imbalances can alter intensity of inflammatory responses. Recombinant human interleukin 37...

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Bibliographic Details
Main Authors: Peitao Zhou, Qianqin Li, Shuwen Su, Wenhui Dong, Suyu Zong, Qiong Ma, Xi Yang, Daming Zuo, Shaoyi Zheng, Xianzhong Meng, Dingli Xu, Qingchun Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
interleukin 37
macrophage polarization
Notch1
NF-κB
calcific aortic valve disease
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00056/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00056/full

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