Model-based design and optimization of GSSR chromatography for peptide purification

Model-based design and optimization of GSSR chromatography for peptide purification

Gradient with Steady State Recycle (GSSR) is a recently developed process for center-cut separation by solvent-gradient chromatography. The process comprises a multicolumn, open-loop system with cyclic steady-state operation that simulates a solvent gradient moving countercurrently with respect to t...

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Bibliographic Details
Main Authors: Tiago P.D. Santos, Rita P. Fernandes, Rui P.P.L. Ribeiro, Cristina Peixoto, José P.B. Mota
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Digital Chemical Engineering
Subjects:
Multicolumn chromatography
Solvent gradient
GSSR process
Process optimization
Interior point method
Optimization under uncertainty
Online Access:http://www.sciencedirect.com/science/article/pii/S2772508122000722

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http://www.sciencedirect.com/science/article/pii/S2772508122000722

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