Megakaryocyte membrane‐wrapped nanoparticles for targeted cargo delivery to hematopoietic stem and progenitor cells

Megakaryocyte membrane‐wrapped nanoparticles for targeted cargo delivery to hematopoietic stem and progenitor cells

Abstract Hematopoietic stem and progenitor cells (HSPCs) are desirable targets for gene therapy but are notoriously difficult to target and transfect. Existing viral vector‐based delivery methods are not effective in HSPCs due to their cytotoxicity, limited HSPC uptake and lack of target specificity...

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Bibliographic Details
Main Authors: Samik Das, Jenna C. Harris, Erica J. Winter, Chen‐Yuan Kao, Emily S. Day, Eleftherios Terry Papoutsakis
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Bioengineering & Translational Medicine
Subjects:
biomimetic
endocytosis
gene regulation
hematopoietic stem cells
membrane‐wrapped
targeted delivery
Online Access:https://doi.org/10.1002/btm2.10456

Internet

https://doi.org/10.1002/btm2.10456

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