Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation

Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation

Human-specific SINE-VNTR-Alu (SVA) retrotransposons in neurodevelopmental genes CDK5RAP2 and SCN8A repress their expression to delay neuronal maturation. SVA-lncRNA AK057321 binds these SVAs to release gene repression and drive neuronal maturation.

Bibliographic Details
Main Authors: Monica J. S. Nadler, Weipang Chang, Ekim Ozkaynak, Yuda Huo, Yi Nong, Morgane Boillot, Mark Johnson, Antonio Moreno, Matthew P. Anderson
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04683-8

Internet

https://doi.org/10.1038/s42003-023-04683-8

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