COMPLEMENT REGULATOR FHR-3 IS ELEVATED EITHER LOCALLY OR SYSTEMICALLY IN A SELECTION OF AUTOIMMUNE DISEASES

COMPLEMENT REGULATOR FHR-3 IS ELEVATED EITHER LOCALLY OR SYSTEMICALLY IN A SELECTION OF AUTOIMMUNE DISEASES

The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system. Homozygous cfhr3/1 deletion is a genetic risk factor for the autoimmune form of hemolytic uremic syndrome (aHUS), whilst also found to be protective in age-related macular degeneration (AMD). The...

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Bibliographic Details
Main Authors: Nicole Schäfer, Antje Grosche, Joerg Reinders, Stefanie Hauck, Richard B. Pouw, Taco W. Kuijpers, Diana Wouters, Boris Ehrenstein, Volker Enzmann, Peter Zipfel, Christine Skerka, Diana Pauly
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
Retinal Degeneration
immune therapy
Rheumatic disease
Specific antibody
FHR-3/ CFHR3
microglia/ macrophages
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00542/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00542/full

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