Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules

Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules

HIV-1 capsid protein (CA) plays an important role in many steps of viral replication and represents an appealing antiviral target. Several CA-targeting small molecules of various chemotypes have been studied, but the peptidomimetic <b>PF74</b> has drawn particular interest due to its pot...

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Bibliographic Details
Main Authors: Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani, Mary C. Casey, Jayakanth Kankanala, Lei Wang, Karen A. Kirby, Haijuan Du, Huanchun Zhang, Philip R. Tedbury, Jiashu Xie, Stefan G. Sarafianos, Zhengqiang Wang
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Viruses
Subjects:
HIV-1
capsid-targeting antivirals
PF74
metabolic stability
Online Access:https://www.mdpi.com/1999-4915/12/4/452

Internet

https://www.mdpi.com/1999-4915/12/4/452

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