Heterogeneous Expression of PD-L1, B7x, B7-H3, and HHLA2 in Pulmonary Sarcomatoid Carcinoma and the Related Regulatory Signaling Pathways

Heterogeneous Expression of PD-L1, B7x, B7-H3, and HHLA2 in Pulmonary Sarcomatoid Carcinoma and the Related Regulatory Signaling Pathways

Immunotherapy has transformed lung cancer management, but PSC remains an aggressive subtype with a poor prognosis. This study investigates the differential expression of PD-L1 and alternative immune checkpoints (ICs; B7x, B7-H3, and HHLA2), and genetic alterations in PSCs. Tumor specimens of 41 PSC...

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Bibliographic Details
Main Authors: Feng Wang, Ayse Ece Cali Daylan, Lei Deng, Jihua Yang, Janaki Sharma, Christopher Su, Shenduo Li, Xingxing Zang, Balazs Halmos, Alain Borczuk, Haiying Cheng
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
immune checkpoint
pulmonary sarcomatoid sarcoma
<i>MET</i>ex14
PD-L1
signaling pathways
Online Access:https://www.mdpi.com/2072-6694/15/13/3372

Internet

https://www.mdpi.com/2072-6694/15/13/3372

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