Blockage of KHSRP-NLRP3 by MCC950 Can Reverse the Effect of Manganese-Induced Neuroinflammation in N2a Cells and Rat Brain

Blockage of KHSRP-NLRP3 by MCC950 Can Reverse the Effect of Manganese-Induced Neuroinflammation in N2a Cells and Rat Brain

Manganese neurotoxicity has been reported to cause a neurodegenerative disease known as parkinsonism. Previous reports have shown that the expression of the KH-type splicing regulatory protein (KHSRP), a nucleic acid-binding protein, and NLRP3 is increased upon Mn exposure. However, the relation bet...

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Bibliographic Details
Main Authors: Sharad Singh, Ibrahim Ahmed Shaikh, Sunil S. More, Mater H. Mahnashi, Hailah M. Almohaimeed, Mohamed El-Sherbiny, Mohammed M. Ghoneim, Ahmad Umar, Harshit Kumar Soni, Himanshu Agrawal, Basheer Ahmed Mannasaheb, Aejaz Abdullatif Khan, Uday M. Muddapur, S. M. Shakeel Iqubal
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
neuroinflammation
KHSRP
manganese neurotoxicity
N2a cells
Parkinson’s
Online Access:https://www.mdpi.com/1422-0067/23/21/13224

Internet

https://www.mdpi.com/1422-0067/23/21/13224

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