Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo

Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo

The abnormal activation of the NLRP3 inflammasome is closely related to the occurrence and development of many inflammatory diseases. Targeting the NLRP3 inflammasome has been considered an efficient therapy to treat infections. We found that dihydrotanshinone I (DHT) specifically blocked the canoni...

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Bibliographic Details
Main Authors: Ziying Wei, Xiaoyan Zhan, Kaixin Ding, Guang Xu, Wei Shi, Lutong Ren, Zhie Fang, Tingting Liu, Xiaorong Hou, Jia Zhao, Hui Li, Jiayi Li, Zhiyong Li, Qiang Li, Li Lin, Yan Yang, Xiaohe Xiao, Zhaofang Bai, Junling Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
dihydrotanshinone I
NLRP3 inflammasome
caspase-1
IL-1β
septic shock
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.750815/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.750815/full

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