Histone Methyltransferase Dot1L Contributes to RIPK1 Kinase‐Dependent Apoptosis in Cerebral Ischemia/Reperfusion

Histone Methyltransferase Dot1L Contributes to RIPK1 Kinase‐Dependent Apoptosis in Cerebral Ischemia/Reperfusion

Background Neuron apoptosis is a pivotal process for brain damage in cerebral ischemia. Dot1L (disruptor of telomeric silencing 1‐like) is only known histone H3K79 methyltransferase. It is not clear whether the role and mechanism of Dot1L on cerebral ischemia is related to regulate neuron apoptosis....

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Bibliographic Details
Main Authors: Jinghuan Wang, Wen Zhong, Haibi Su, Jie Xu, Di Yang, Xinhua Liu, Yi Zhun Zhu
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cIAP
CYLD
Dot1L
middle cerebral artery occlusion
oxygen‐glucose deprivation
RIPK1
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.022791

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.022791

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