Crosstalk between Tumor Cells and Macrophages in Stroma Renders Tumor Cells as the Primary Source of MCP-1/CCL2 in Lewis Lung Carcinoma

Crosstalk between Tumor Cells and Macrophages in Stroma Renders Tumor Cells as the Primary Source of MCP-1/CCL2 in Lewis Lung Carcinoma

The chemokine MCP-1/CCL2 is produced by a variety of tumors and plays an important role in cancer progression. We and others previously demonstrated that the primary source of MCP-1 in several mouse tumors, including 4T1 breast cancer, M5076 sarcoma and B16 melanoma, was stromal cells. In the pres...

Full description

Bibliographic Details
Main Authors: Teizo eYoshimura, Mingyong eLiu, Xin eChen, Liangzhu eLi, Ji Ming eWang
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Immunology
Subjects:
Chemokines
Inflammation
Tumor Microenvironment
lung cancer
monocytes/macrophages
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00332/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00332/full

Similar Items