Microgravity Induces Transient EMT in Human Keratinocytes by Early Down-Regulation of E-Cadherin and Cell-Adhesion Remodeling

Microgravity Induces Transient EMT in Human Keratinocytes by Early Down-Regulation of E-Cadherin and Cell-Adhesion Remodeling

Changes in cell–matrix and cell-to-cell adhesion patterns are dramatically fostered by the microgravity exposure of living cells. The modification of adhesion properties could promote the emergence of a migrating and invasive phenotype. We previously demonstrated that short exposure to the simulated...

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Bibliographic Details
Main Authors: Giulia Ricci, Alessandra Cucina, Sara Proietti, Simona Dinicola, Francesca Ferranti, Marcella Cammarota, Antonio Filippini, Mariano Bizzarri, Angela Catizone
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Applied Sciences
Subjects:
simulated microgravity
focal adhesion
vinculin
E-cadherin
cytoskeleton
HaCaT cells
Online Access:https://www.mdpi.com/2076-3417/11/1/110

Internet

https://www.mdpi.com/2076-3417/11/1/110

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