Effects of the Lipophilic Core of Polymer Nanoassemblies on Intracellular Delivery and Transfection of siRNA

Despite effective gene silencing in vitro, in vivo delivery and transfection of siRNA remain challenging due to the lack of carriers that protect siRNA stably in the body. This study is focused to elucidate the correlation between complex stability and transfection efficiency of siRNA carriers. The...

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Bibliographic Details
Main Authors: Steven Rheiner, Piotr Rychahou, Younsoo Bae
Format: Article
Language:English
Published: AIMS Press 2015-07-01
Series:AIMS Biophysics
Subjects:
Online Access:http://www.aimspress.com/biophysics/article/345/fulltext.html