Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease

Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease

<p>Abstract</p> <p>Background</p> <p>Passive immunization with antibodies directed to Aβ decreases brain Aβ/amyloid burden and preserves memory in transgenic mouse models of Alzheimer's disease (AD). This therapeutic strategy is under intense scrutiny in clinical s...

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Bibliographic Details
Main Authors: Bosetti Francesca, Wetzel Ronald, Dealwis Chris, Prendergast Jay S, Rebeck G William, Mocchetti Italo, Niikura Takako, Aid Saba, Shimoji Mika, Sidahmed Elkhansa, Minami S Sakura, Matsuoka Yasuji, Hoe Hyang-Sook, Turner R Scott
Format: Article
Language:English
Published: BMC 2010-09-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/7/1/57

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http://www.jneuroinflammation.com/content/7/1/57

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