Mechanisms of Smoothened Regulation in Hedgehog Signaling

Mechanisms of Smoothened Regulation in Hedgehog Signaling

The seven-transmembrane protein, Smoothened (SMO), has shown to be critical for the hedgehog (HH) signal transduction on the cell membrane (and the cilium in vertebrates). SMO is subjected to multiple types of post-translational regulations, including phosphorylation, ubiquitination, and sumoylation...

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Bibliographic Details
Main Authors: Jie Zhang, Zulong Liu, Jianhang Jia
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
hedgehog signaling
smoothened
phosphorylation
ubiquitination
cholesterol
phospholipid
Online Access:https://www.mdpi.com/2073-4409/10/8/2138

Internet

https://www.mdpi.com/2073-4409/10/8/2138

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