Identification of hub genes and key signaling pathways by weighted gene co-expression network analysis for human aortic stenosis and insufficiency

Identification of hub genes and key signaling pathways by weighted gene co-expression network analysis for human aortic stenosis and insufficiency

BackgroundHuman aortic valve stenosis (AS) and insufficiency (AI) are common diseases in aging population. Identifying the molecular regulatory networks of AS and AI is expected to offer novel perspectives for AS and AI treatment.MethodsHighly correlated modules with the progression of AS and AI wer...

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Bibliographic Details
Main Authors: Yang Yang, Bing Xiao, Xin Feng, Yue Chen, Qunhui Wang, Jing Fang, Ping Zhou, Xiang Wei, Lin Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
aortic valve stenosis
aortic valve insufficiency
heart failure
WGCNA
co-expression modules
hub genes
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.857578/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2023.857578/full

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